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Xiayin Zhang
Xiayin Zhang

Xiayin Zhang

Research Collaborator

Research Fellow I

Ocular Epidemiology Research Group, Singapore Eye Research Institute (SERI)

Biography

Xiayin Zhang is a Research Fellow I at the Singapore National Eye Centre (SNEC), working with the Ocular Epidemiology Research Group at the Singapore Eye Research Institute (SERI). Her research leverages large-scale data mining and translational approaches to investigate the genetic and molecular basis of eye diseases, with a particular focus on integrating oculomics and multi-omics strategies for precision medicine. She has published over 80 papers in journals including Nature Medicine, JAMA Network Open and Progress in Retinal and Eye Research, and has secured competitive funding through grants such as the National Natural Science Foundation of China Young Scientist Award and the SingHealth Duke-NUS Academic Medicine Research Grant. She also serves as Managing Editor of Visual Neuroscience (SCI Journal).

Professional Experience

  • Present | Research Fellow I, Singapore National Eye Centre, Singapore
  • Present | Managing Editor, Visual Neuroscience (SCI Journal)
  • 01/2025–06/2025 | Research Associate Professor, Guangdong Provincial People’s Hospital, China
  • 07/2024–06/2025 | Clinical Fellowship, Guangdong Provincial People’s Hospital, China
  • 07/2021–06/2024 | Resident, Guangdong Provincial People’s Hospital, China
  • 07/2021–07/2024 | Postdoc, Guangdong Provincial People’s Hospital, China

Education

  • Ph.D. in Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, China (2021)
  • M.D. in Clinical Medicine, Zhongshan School of Medicine, Sun Yat-sen University, China (2016)

Contact

Awards and Honors

  1. National Health Commission, National Digital Health Innovation Application Competition - Medical Artificial Intelligence Theme, Provincial First Prize, 2024

    Zhang Xiayin (4/6); Intelligent Diagnosis and Automated Report Generation System for Retinopathy of Prematurity.

  2. Guangdong Medical Association, Medical Science and Technology Award, Provincial First Prize,2025

    Zhang Xiayin (5/13); Establishment and Application of an Intelligent Diagnosis and Treatment System for Heart, Brain, and Kidney Diseases Based on Multidimensional Quantification of Fundus Images.

  3. ARVO Foundation Travel Grant. ARVO Annual Meeting, New Orleans, US. 2023

  4. ARVO Research Career Travel Grant. ARVO Annual Meeting, Denver, US. 2026

Selected Representative Publications

  1. Zhang X#, Li Q#, Liang Y#, Lai C#, …, Cheng CY, Yu H. (2026). AI framework for multidisease detection via retinal imaging. Nature medicine. 2026 10.1038/s41591-026-04359-w. IF 52.50

  2. Zhu Z**#*, Wang Y#, Qi Z#, Hu W#**, Zhang X#, Wagner SK, Wang Y, Ran AR, Ong J, Waisberg E, Masalkhi M, Suh A, Tham YC, Cheung CY, Yang X, Yu H, Ge Z, Wang W, Sheng B, Liu Y, Lee AG, Denniston AK, Wijngaarden PV, Keane PA, Cheng CY, He M, Wong TY*. Oculomics: Current concepts and evidence. Prog Retin Eye Res. 2025 Mar 4;106:101350. IF 18.70

  3. Zhang X#, Shang X, Seth I, Huang Y, Wang Y, Liang Y, Du Z, Wu G, Hu Y, Liu S, Hu Y, He M, Zhu Z, Yang X*, Yu H*. Association of visual health with depressive symptoms and brain imaging phenotypes among middle-aged and older adults. JAMA Netw Open. 2022 Oct 3;5(10):e2235017. IF 10.50

  4. Zhang X#, Wang S**#, Du Z#**, Seth I, Wang Y, Liang Y, Wu G, Huang Y, Liu S, Hu Y, Shang X, Hu Y, Zhu Z*, Yu H*. The associations and mediators between visual disabilities and anxiety disorders in middle-aged and older adults: A population-based study. Am Psychol. 2023 Nov;78(8):982-994. IF 12.30

  5. Zhang X#, Wang S**#, Huang Y#, Xie Y#**, Seth I, Bulloch G, Lai C, Hu Y, Shang X, He M, Zhu Z*, Yu H*. Exploring Effects of Age at the Onset of Myopia on Multiple Diseases Using Electronic Health Records. Ophthalmology Science. 2025 Sep;5(5):100819 IF 3.2

  6. Zhang X#, Wang S**#, Wang Y#, Jia F#**, Wagner SK, Wang Y, Li Q, Ran A, Li C, Cao J, Yang Y, Hu Y, Liu L, Cheung CY, Keane PA, Cheng CY, Yang X, Zhu Z, Yu H. Optic disc morphometrics as a potential ocular biomarker for depression: evidence from two cross-sectional cohort studies. Transl Psychiatry. 2025 Oct 31;15(1):465. IF 7.5

  7. Zhang X#, Liang Y**#, Huang Y#, Liu S#**, Li Q, Wang S, Wu G, Du Z, Wang Y, Wang J, Hu Y, Zang S, Hu Y, Shang X, Zhang X, Zhang L, Brown A, Zhu Z, He M*, Yu H*. Evaluation of the observational associations and shared genetics between glaucoma with depression and anxiety. Invest Ophthalmol Vis Sci. 2024 Mar 5;65(3):12. IF 5.0

  8. Zhang X#, Xiao H**#, Liu C#, Zhao L#**, Wang J, Li H, Wang R, Zhu Y, Chen C, Wu X, Lin D, Wang J, Liu X, Qiu W, Yu-Wai-Man P, Ting DS, Lin H*. Comparison of macular structural and vascular changes in neuromyelitis optica spectrum disorder and primary open angle glaucoma: a cross-sectional study. Br J Ophthalmol. 2021 Mar;105(3):354-360. IF 3.7

  9. Zhang X#, Wang D**#**, Dongye M, Zhu Y, Chen C, Wang R, Long E, Liu Z, Wu X, Lin D, Chen J, Lin Z, Wang J, Li W, Li Y, Li D, Lin H. Loss-of-function mutations in FREM2 disrupt eye morphogenesis. Exp Eye Res. 2019 Apr;181:302-312. IF 3.0

  10. Zhang X#, Wang S**#, Liu S#**, Du Z, Wu G, Liang Y, Huang Y, Shang X, Hu Y, Zhu Z, Sun W*, Zhang X*, Yu H*. Epidemiologic association and shared genetic architecture between cataract and hearing difficulties among middle-aged and older adults. Hum Genomics. 2024 Mar (accepted). IF 4.50

  11. Huang Y**#, Plotnikov D#, Wang H#, Shi D#**, Li C, Zhang X, Zhang X, Tang S, Shang X, Hu Y, Yu H*, Zhang H*, Guggenheim JA*, He M*. GWAS-by-subtraction reveals an IOP- independent component of primary open angle glaucoma. Nat Commun. 2024 Oct 17;15(1):8962. IF 14.7

  12. Zhang X**#, Kong L#, Liu S#, Zhang X#, Shang X, Zhu Z, Huang Y, Ma S, Jason H, Kiburg KV, Zheng C, Hu Y, Li C, Wu G, Liang Y, He M, Wang Y, Bai X, Shi D, Wang W, Zhang C, Zhao K, Yuan H, Hu G, Hu Y, Liang H*, Yu H*, Zhang L*, He M***. EBD: an eye biomarker database. Bioinformatics. 2023 May 4;39(5):btad194. IF 4.4

  13. Zhang X#, Wu X, Lin Z, Lin H*. Conjunctival eyelashes. BMJ. 2017 Aug;358:j3486. [Case] IF 93.6

  14. Lai C**#, Su T#**, Cao J, Li Q, Du Z, Wang Y, Wang S, Wu Q, Hu Y, Fang Y, Liao H, Zhu Z, Shang X, He M*, Yu H*, Zhang X*. Retinal Neurovascular Impairment in Full-Course Diabetic Retinopathy: The Guangdong Diabetic Retinopathy Multiple-Omics Study. Invest Ophthalmol Vis Sci. 2024 Dec 2;65(14):20. IF 5.0

  15. Cao J, Liu F, Kong H, Lai C, Du Z, Soh ZD, Su T, Shen C, Li Q, Fang Y, Hu Y, Shang X, Shen X, He M, Cheng CY, Zhu Z, Zhou M***, Zhang X*, Yu H***. Integrated intraocular-plasma proteomics reveals conserved biomarkers for diabetic retinopathy progression: a multi-fluid biopsy study. Diabetologia. 2026 Jul;69(7):1823-1838. IF 10.4

ORCID